Multiple Sclerosis

Rob Nuttall, Caroline Pennington

Matrix metalloproteinases (MMPs) are implicated in multiple sclerosis (MS) where their roles may be to facilitate the transmigration of circulating leukocytes into the central nervous system, as well as in promotion of the immune response. Studies to date have focused on only a few enzymes and much remains unknown of which MMP, ADAM, and/or inhibitor members is/are critical to the MS disease process. We have used qPCR to profile all MMPs, ADAMs, and TIMPs in human leukocytes from patients with or without MS, and in tissues from mice that have experimental allergic encephalomyelitis (EAE) as a model of MS.